Appropriate preposition

 Use of inspite of

If something exist to restrict something to happen,  but yet consequence is happened. In that case inspite of is uses. 

Example, Inspite of my illness I went to school. 

Inspite of having fever I sat on exam

Use of despite

Use of despite is similar to inspite of. We may use despite instead of inspite of

Regardless of

If something happened without considering any quality

I got the job regardless of my academic resalt. 

On uses to mean something is up but touched

The book is on the table

Over uses to mean something is up but non touched

The bird flew over the tree

In and at

In uses before big place but at uses before small place in the big place

I live at katiadi in kishoregonj

Into uses to mean something placed in somewhere with motion and direction

He threw stone into water.